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This episode is also brought to you by Heron Therapeutics. Please see full Prescribing Information, including Boxed Warning or visit www.ZYNRELEF.com.

Dr. William B. Kurtz is a board-certified, fellowship-trained orthopedic surgeon who specializes in hip and knee replacements at Tennessee Orthopaedic Alliance.

Dr. Kurtz holds a bachelor’s degree in mechanical engineering from Rice University. He graduated medical school from The University of Texas Southwestern Medical School at Dallas with Alpha Omega Alpha honors distinction. He completed a residency in orthopedic surgery at Vanderbilt University Medical Center, followed by a subspecialty fellowship in adult reconstructive joint surgery at New England Baptist Hospital in Boston.

Topics include:

-His role in Ortho Founders, a place where orthopreneurs can pitch their innovations and gain feedback from other leaders in orthopedics.

-Dr. Will Kurtz is President of Tennessee Orthopaedic Alliance, a group of 106 physicians. He is also a board member in Ortho Forum, whose members comprise 100 private practice groups across the U.S. to share data analysis and best practices on revenue cycle management and ancillary revenue streams.

-He’s done over 10,000 Conformis knees, made specifically for the patient. Dr. Kurtz breaks down the difference between Conformis personalized knees and a standard total knee, which comes off-the-shelf.

-We discuss his recent business case study in Journal Orthopaedic Experience and Innovation, Value Creation vs Value Capture in Orthopedics.

Find out more about Dr. Will Kurtz here.

Also, find out more about Zynrelef here:

ZYNRELEF utilizes a novel synergistic mechanism of action that combines bupivacaine with a low dose of meloxicam to overcome the challenges of the inflammatory process at the surgical site. ZYNRELEF is the first and only extended-release dual-acting local anesthetic (DALA) and delivers 72 hours of postoperative pain relief via a single needle-free application. It has been clinically proven to better manage pain than standard of care bupivacaine HCl solution over 72 hours and to significantly reduce opioid utilization following surgery.

-ZYNRELEF was initially approved by the FDA in May 2021 and in December 2021, the FDA approved an expansion of ZYNRELEF’s indication.

-Limitations of Use: Safety and efficacy have not been established in highly vascular surgeries, such as intrathoracic, large multilevel spinal, and head and neck procedures.

WARNING: RISK OF SERIOUS CARDIOVASCULAR AND GASTROINTESTINAL EVENTS

See full prescribing information for complete boxed warning.

• Nonsteroidal anti-inflammatory drugs (NSAIDs) cause an increased risk of serious cardiovascular thrombotic events, including myocardial infarction and stroke, which can be fatal. This risk may occur early in treatment and may increase with duration of use

• ZYNRELEF is contraindicated in the setting of coronary artery bypass graft (CABG) surgery

• NSAIDs cause an increased risk of serious gastrointestinal (GI) adverse events including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal. These events can occur at any time during use and without warning symptoms. Elderly patients and patients with a prior history of peptic ulcer disease and/or GI bleeding are at greater risk for serious GI events

ZYNRELEF is contraindicated for:

• Patients with a known hypersensitivity (e.g., anaphylactic reactions and serious skin reactions) to any local anesthetic agent of the amide-type, NSAIDs, or to any of the other components of ZYNRELEF OR history of asthma, urticaria, or other allergic-type reactions after taking aspirin or other NSAIDs. Severe, sometimes fatal, anaphylactic reactions to NSAIDs have been reported in such patients

• Patients undergoing obstetrical paracervical block anesthesia OR coronary artery bypass graft (CABG) surgery

WARNINGS AND PRECAUTIONS include –

Cardiovascular (CV) Thrombotic Events with NSAID Use; Gastrointestinal Bleeding, Ulceration, and Perforation with NSAID Use; Dose-Related Toxicity; Risk of Use in Patients with Impaired Cardiovascular Function; Hepatotoxicity; Hypertension; Heart Failure and Edema; Renal Toxicity and Hyperkalemia; Anaphylactic Reactions; Chondrolysis; Methemoglobinemia; Exacerbation of Asthma Related to Aspirin Sensitivity; Serious Skin Reactions; Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS); Hematologic Toxicity; Masking of Inflammation and Fever.